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moradec
Moradec LLC由Helen（Hongyuan）Mao博士于2012年創(chuàng)立，主要目標(biāo)是為快速經(jīng)濟(jì)的抗體-藥物偶聯(lián)物發(fā)現(xiàn)提供新的研究工具，加速抗體藥物共軛物（ADC）的發(fā)現(xiàn)，這是一種針對(duì)癌癥的靶向治療。它們的二級(jí)抗體-藥物共軛物（2°ADC）與各種細(xì)胞毒性藥物如MMAE、MMAF、DM1或Duocarmycin連接，為快速、經(jīng)濟(jì)有效的方式預(yù)篩選針對(duì)癌細(xì)胞具有相關(guān)作用機(jī)制的靶抗體提供了可能。由一種與細(xì)胞毒性藥物連接的抗體組成，已成為一種新的針對(duì)癌癥的靶向治療方法。
抗體偶聯(lián)物（ADC）由抗體與細(xì)胞毒性藥物連接而成，通過(guò)單克隆抗體部分選擇性地結(jié)合到目標(biāo)癌細(xì)胞。內(nèi)化后，藥物釋放出來(lái)作用于癌細(xì)胞，實(shí)現(xiàn)了對(duì)腫瘤細(xì)胞的特異性殺傷，同時(shí)極大程度減少了細(xì)胞毒性藥物對(duì)全身的毒性。
在細(xì)胞基礎(chǔ)的毒性試驗(yàn)中使用2°ADC消除了直接將每個(gè)單克隆抗體與細(xì)胞毒性藥物偶聯(lián)的必要性，節(jié)省了與純化和偶聯(lián)相關(guān)的時(shí)間和成本。通過(guò)在2°ADC存在的情況下直接將裸抗體添加到細(xì)胞中，可以實(shí)現(xiàn)類似于單克隆抗體-藥物共軛物中細(xì)胞內(nèi)劑量依賴的藥物釋放效應(yīng)，而不會(huì)影響表達(dá)目標(biāo)受體水平較低的細(xì)胞。
Moradec的2°ADC表現(xiàn)出高度特異性，在沒(méi)有主要抗體的情況下對(duì)細(xì)胞毒性極小，并且在未結(jié)合的二級(jí)抗體存在的情況下保持主要抗體的活性。這種方法簡(jiǎn)化了ADC的開(kāi)發(fā)過(guò)程，增強(qiáng)了篩選和選擇用于靶向癌癥治療的最佳抗體藥物共軛物的效率。
Moradec的2°ADC具有高度特異性，在缺乏初級(jí)抗體的情況下對(duì)細(xì)胞的毒性最小。在存在未偶聯(lián)的第二抗體的情況下，第一抗體活性沒(méi)有明顯變化。
Moradec的2°ADC使得能夠快速篩選主要抗體引物，以確定最佳候選者用于特定ADC的開(kāi)發(fā)。提供了一系列具有可切割或不可切割連接子的2°ADC，有助于測(cè)試針對(duì)特定細(xì)胞系的多種藥物-連接子組合，以優(yōu)化ADC格式。這些2°ADC也可應(yīng)用于重組蛋白配體，用于靶向細(xì)胞表面受體。
部分產(chǎn)品信息
貨號(hào) | 產(chǎn)品名稱 | 描述 | 規(guī)格 |
AH-101AF-50 | αHFc-NC-MMAF | IgGs Anti-Human IgG Fc-MMAF Antibody with Non-Cleavable Linker | 50µg |
AH-103D1-50 | αHFc-NC-DM1 | IgGs Anti-Human IgG Fc-DM1 Antibody with Non-Cleavable Linker | 50µg |
AH-201AF-50 | Fab-αHFc-NC-MMAF | Fab Anti-Human IgG Fc-MMAF Antibody with Non-Cleavable Linker | 50µg |
AH-121AF-50 | αHFab-NC-MMAF | IgGs Anti-Human IgG Fab-MMAF Antibody with Nonceavable Linker | 50µg |
AM-101AF-50 | αMFc-NC-MMAF | IgGs Anti-Mouse IgG Fc-MMAF Antibody with Non-Cleavable Linker | 50µg |
AO-101AF-50 | αOFc-NC-MMAF | IgGs Anti-Rabbit IgG Fc-MMAF Antibody with Non-Cleavable Linker | 50µg |
更多其它產(chǎn)品詳情請(qǐng)查詢Moradec網(wǎng)站或咨詢Moradec中國(guó)代理上海起發(fā)。
下圖為Moradec公司授權(quán)上海起發(fā)作為中國(guó)區(qū)域代理的授權(quán)書(shū)。
Moradec熱賣產(chǎn)品
貨號(hào) | 產(chǎn)品名稱 | 規(guī)格 | 品牌 |
AH-102AE-50 | αHFc-CL-MMAE | 50μg | Moradec |
AH-102AF-50 | αHFc-CL-MMAF | 50μg | Moradec |
AH-202AE-50 | Fab-αHFc-CL-MMAE | 50μg | Moradec |
AH-106PB-50 | αHFc-CL-PBD | 50μg | Moradec |
AH-101AF-50 | αHFc-NC-MMAF | 50μg | Moradec |
AH-107DX-50 | αHFc-CL-DX8951 | 50μg | Moradec |
AM-102AE-50 | αMFc-CL-MMAE | 50μg | Moradec |
AH-207DX-50 | Fab-αHFc-CL-DX8951 | 50μg | Moradec |
AM-102AF-50 | IgGs Anti-Mouse IgG Fc-MMAF Antibody with Cleavable Linker | 50μg | Moradec |
AH-202AF-50 | Fab Anti-Human IgG Fc-MMAF Antibody with Cleavable Linker 50µg | 50μg | Moradec |
AH-122AE-50 | IgGs Anti-Human IgG Fab-MMAE Antibody with Cleavable Linker 50µg | 50μg | Moradec |
AM-107DX-50 | αMFc-CL-DX8951 | 50μg | Moradec |
AM-202AE-50 | Fab-αMFc-CL-MMAE | 50μg | Moradec |
AH-201AF-50 | Fab-αHFc-NC-MMAF | 50μg | Moradec |
AM-106PB-50 | αHFc-CL-PBD | 50μg | Moradec |
AH-102PN-50 | αHFc-CL-PNU | 50μg | Moradec |
AH-202AE-20 | Fab-αHFc-CL-MMAE | 20μg | Moradec |
AH-102AE-20 | αHFc-CL-MMAE | 20μg | Moradec |
AM-103D1-50 | IgGs Anti-Mouse IgG Fc-DM1 Antibody with Non-Cleavable Linker 50µg | 50μg | Moradec |
AM-202AE-20 | Fab-αMFc-CL-MMAE | 20μg | Moradec |
AM-101AF-50 | IgGs Anti-Mouse IgG FC-MMAF Antibody with Non-CleavableLinker | 50μg | Moradec |
AH-202DD-50 | Fab Anti-Human IgG Fc-Duocarmycin DM Antibody with Cleavable Linker 50µg | 50μg | Moradec |
AH-103D1-50 | IgGs Anti-Human IgG Fc-DM1 Antibody with Non-Cleavable Linker 50µg | 50μg | Moradec |
AM-201AF-50 | Fab-αMFc-NC-MMAF | 50μg | Moradec |
AH-203D1-20 | Fab Anti-Human IgG Fc-DM1 Antibody with Non-Cleavable Linker 20µg | 20μg | Moradec |
AM-203D1-20 | Fab Anti-Mouse IgG Fc-DM1 Antibody with Noncleavable Linker 20µg | 20μg | Moradec |
AM-107DX-20 | IgGs Anti-Mouse IgG Fc-DX8951 Antibody with Cleavable Linker 20µg | 20μg | Moradec |
AM-203D1-50 | Fab-αMFc-NC-DM1 | 50μg | Moradec |
AO-112AE-20 | IgGs Anti-Rabbit IgG(H+L)-MMAE Antibody with Cleavable Linker 20µg | 20μg | Moradec |
AO-112AE-50 | IgGs Anti-Rabbit IgG(H+L)-MMAE Antibody with Cleavable Linker 50µg | 50μg | Moradec |
AM-103D1-20 | IgGs Anti-Mouse IgG Fc-DM1 Antibody with Non-Cleavable Linker 20µg | 20μg | Moradec |
AM-102AE-20 | αMFc-CL-MMAE | 20μg | Moradec |
AM-102-AE-50 | αMFc-CL-MMAE | 50μg | Moradec |
AH-207DX-20 | Fab Anti-human IgG Fc-DX8951 Antibody with Cleavable Linker 20µg | 20μg | Moradec |
AH-202-AE | Fab-αHFc-CL-MMAE | ea | Moradec |
AH-122AF-50 | IgGs Anti-Human IgG Fab-MMAF Antibody with Cleavable Linker 50µg | 50μg | Moradec |
AH-102-AE | αHFc-CL-MMAE | ea | Moradec |
AH-123D1-50 | IgGs Anti-Human IgG Fab-DM1 Antibody with Non-Cleavable Linker 50µg | 50μg | Moradec |
AH-121AF-50 | IgGs Anti-Human IgG Fab-MMAF Antibody with Nonceavable Linker 50µg | 50μg | Moradec |
AH-102AF-20 | IgGs Anti-Human IgG Fc-MMAF Antibody with Cleavable Linker 20µg | 20μg | Moradec |
AH-102AE-50 | αHFc-CL-MMAE | 50μg | Moradec |
AH-102AF-50 | αHFc-CL-MMAF | 50μg | Moradec |
AH-202AE-50 | Fab-αHFc-CL-MMAE | 50μg | Moradec |
AH-106PB-50 | αHFc-CL-PBD | 50μg | Moradec |
AH-101AF-50 | αHFc-NC-MMAF | 50μg | Moradec |
AH-107DX-50 | αHFc-CL-DX8951 | 50μg | Moradec |
AM-102AE-50 | αMFc-CL-MMAE | 50μg | Moradec |
AH-207DX-50 | Fab-αHFc-CL-DX8951 | 50μg | Moradec |
AM-102AF-50 | IgGs Anti-Mouse IgG Fc-MMAF Antibody with Cleavable Linker | 50μg | Moradec |
AH-202AF-50 | Fab Anti-Human IgG Fc-MMAF Antibody with Cleavable Linker 50µg | 50μg | Moradec |
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